Trojan-Horse Therapy- New Hope for Metastasis Cancer Patients

Metastasis Cancer 

It is actually spreading of Cancer Cells from the place where it first started to another place in the body. Any type of Cancer can turn into Metastatic cancer. Metastatic cancer has the same name and the same type of cancer cells as the original, or primary, cancer. For example, breast cancer that spreads to the lungs and forms a metastatic tumor is metastatic breast cancer, not lung cancer.

Persons who have been already treated for cancer are at a high risk of developing metastasis cancer.

Mode of Metastasis

Cancer Cells metastasize by gaining access to the circulatory system, which includes Blood, vessels to transport the blood, and a heart to pump the blood, lymphatic system . Once inside a blood vessel, cancer cells can drift virtually anywhere in the body.
Cancer cells differ from normal cells in three ways:
(1) they divide when they should not;
(2) they invade surrounding tissues; and
(3) they move to other locations in the body.
Any tissue that undergoes cell division is susceptible to becoming cancerous.

Metastasis

A common cancer cell spreading pattern. Development of metastasis cancerous cell.

Fact 

The survival rate is very low in case of Cancer become metastasis. Even with continuous chemotherapy, chances of survival is very low.

Survival Rate (For five-year Period) : 70%

Survival Rate (After five-year Period): 10-20%

To See Study on survival rate of Metastasis Breast Cancer: Click Here

Treatment

1. Only few metastatic cancer can be cured to currents treatments.

2. In most cases of metastatic cancer, the goal of treatment is to control the growth of the cancer or to relieve the symptoms. Most cases, the death of cancer is due to metastatic cancer. Treatment only prolongs life. No Cure at the moment.

Future Outlook of Treatment

Metastasis Cancer treatment future outlook is still in nascent stage. Not a single method of treatment is tested outside the lab till now. There is two or three techniques which has shown promising results on animals. You might want to participate in the clinical trails if your cancer has stopped responding to the chemotherapy and radiation therapy.

Trojan Horse Therapy:   

In this therapy, viruses attack the cancerous cells. The White Blood cells are mixed with the viruses which further delivers viruses inside the body. A research group in UK under Dr Emma Smith takes blood samples and extract macrophages (a part of the immune system which normally attacks foreign invaders).

Properties of Viruses Used

1. Avoid being attacked like HIV.

2. Travels with White Blood Cell.

In the study, the mice were injected with the white blood cells two days after a course of chemotherapy ended.

At this stage each white blood cell contained just a couple of viruses. However, once the macrophages enter the tumour the virus can replicate. After about 12 hours the white blood cells burst and eject up to 10,000 viruses each – which go on to infect, and kill, the cancerous cells.

Mechanism of Action: The oncolytic viruses divide themselves in the white blood cells. The division keeps going on until the cell burst takes place and viruses deliver into Cancerous cells.

This therapy needs to do simultaneous with the chemotherapy or radiation therapy as the white blood cells formed at a rapid pace after chemo in order to mitigate the damage of body from chemo. So, rapid formation of WBC’s help in viruses to divide in more number.

Promising Result:

Mice has been completely cured from the metastasis Prostate cancer after 40 days this treatment  in comparison to other mice who has been died without this therapy.

But, the research is still at an early stage and tests to show it is safe and effective in humans are still needed.

Link to research article : Click Here

Link to news article: Click Here

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